Cardiovascular Health Maintenance 

The heart, a vital organ in our bodies beats about 2.5 billion times in an average lifetime. It functions 24/7, pumping slightly less than 2000 gallons of blood per day for the average person. It is one of the most essential organs keeping the human body alive. When the heart stops, other systems fail almost instantly. Simple life changes that benefit heart health include losing/maintaining weight, eating healthy, staying active, reducing cholesterol, reducing blood pressure, and taking supplements.   

The term ‘cardiovascular’ refers to the structures and processes within the circulatory system. The circulatory system consists of the heart as well as the blood vessels that carry nutrients and oxygen to the tissues of the body and remove carbon dioxide and waste from them. Cardiovascular disease occurs when there is damage or dysfunction in the heart or blood vessels.   

Cardiovascular diseases are conditions that affect the heart and blood vessels and include arteriosclerosis, coronary artery disease, heart valve disease, arrhythmia, heart failure, hypertension, orthostatic hypotension, shock, endocarditis, diseases of the aorta and its branches, disorders of the peripheral vascular system, and congenital heart disease.  

Heart disease is the leading cause of death in the United States1. Stroke is the fifth leading cause of death in the United States. Together, heart disease and stroke, along with other cardiovascular diseases, are among the most widespread and costly health problems facing the nation today, accounting for approximately $320 billion in health care expenditures and related expenses annually.2   

Fortunately, they are also among the most preventable.   

What is Coenzyme Q10 (CoQ10)?  

Coenzyme Q10 (CoQ10) is vital for cellular energy and cardiovascular health. Found in almost every cell of the body, CoQ10 is a fat-soluble, vitamin-like substance that helps convert food into energy. A powerful antioxidant that protects against damage from toxic free radicals, CoQ10 is produced by the body and is also found in many foods, with higher levels in organ meats, such as liver or kidneys; as well as sardines, mackerel, chicken, cauliflower, broccoli and asparagus.  

CoQ10, the third most consumed nutritional supplement behind fish oil and multivitamins, is a compound that is synthesized by the body.3  CoQ10 is a member of the coenzyme Q family of compounds, also called ubiquinone because they are ubiquitous in living cells. CoQ10 is the most common form in humans.  

CoQ10 plays a central role in the cellular energy production.  It is directly involved in the creation of ATP in the mitochondria of all cells. CoQ10 also functions as a powerful antioxidant in cell membranes and lipoproteins.  In addition, CoQ10 regenerates other “used up” antioxidants (vitamin E and vitamin C), restoring their antioxidant activity in the body. 

With age, CoQ10 levels decline naturally, accompanying the age-related decline in energy metabolism observed in liver, heart, and muscle tissue.4 Use of certain statin medications can also reduce body CoQ10 levels.5   

Research suggests that CoQ10 may be a beneficial supplement to take for maintaining a healthy cardiovascular system. The dosage of CoQ10 researched for cardiovascular health support ranges from 100-300 mg daily.     

CoQ10 supplements can help support healthy cholesterol (HDL) levels, which is known to be an indicator of good cardiovascular health.  CoQ10 supplementation has also been shown to help support healthy levels of CRP, a biomarker used to identify cardiovascular health risk.6 Low levels of CoQ10 have been linked to poorer cardiovascular health outcomes.   

In an analysis of 12 clinical studies, researchers reported that CoQ10 was able to support healthy blood pressure levels.  A meta-analysis of 17 small trials also supports the ability of CoQ10 supplementation to support healthy blood pressure. 7    

A 2012 meta-analysis examining the results of five small randomized controlled trials in 194 subjects in total found that supplemental coenzyme Q10 (150-300 mg/day for 4 to 12 weeks) resulted in a clinically significant, 1.7% increase in flow-dependent endothelial-mediated dilation. 8   

The typical dose of CoQ10 supplements is 100 mg/day, however, absorption of different CoQ10 formulations varies widely.  CoQ10 is strongly lipophilic (insoluble in water) and best absorbed with fat in a meal.  CoQ10 supplements are available as tablets (chewable and non-chewable), capsules, and soft gels containing oil suspensions of CoQ10.  The bioavailability of powdered CoQ10 in many products is very low.  Formulations of CoQ10 solubilized in oil possess superior bioavailability.     

VitaSperse CoQ10 Delivery   

VitaSperse CoQ10 is a unique water-dispersible microemulsion of CoQ10.  There is no contest when comparing to other liposomal/oil solubilized CoQ10s if one is formulating for inclusion in a water-based delivery system.  

VitaSperse CoQ10 is a unique, researched form of CoQ10 that combines two techniques proven to enhance absorption in the body: emulsification and micro-sized particles, yielding a microemulsion. VitaSperse CoQ10 is a water-dispersible CoQ10 that is clinically shown to increase body levels of CoQ10.  VitaSperse CoQ10 can be consumed on its own as liquid drops, included in any ready-to-drink formula, or added as an antioxidant to any cosmetic.  

All VitaSperse ingredients start with reverse osmosis water.  Only food grade ingredients are used to create VitaSperse formulations.  Lecithins and non-ionic surfactants are the main building blocks of the VitaSperse microemulsion.  Then, a preservative system is added, depending upon use and customer preference (i.e. VitaSperse can be used for topical formulations, too – they require a different preservative system to be cosmetic compliant).  The VitaSperse process itself will encapsulate/protect nutritional actives, but additional ingredients can be included for added stability support of active ingredients.   

Next, the VitaSperse mixture is processed through a high shear microfluidizer.  High shear forces produce a uniform dispersion of incredibly small particles encapsulated by lipids.  Because these particles are so small and carry a charge, they stay suspended in water via Brownian Motion (think dust motes floating in air – without air currents).  VitaSperse dispersions will stay suspended in a product indefinitely.   

VitaSperse CoQ10 has been shown to increase bioavailability compared to traditional forms of CoQ10. Different forms of CoQ10 were put through a simulated gastric digestion, after which CoQ10 uptake into cells (Caco-2) was measured.  Products tested were chewable tablets, a soft gel containing a solubilized CoQ10, and a gamma-cyclodextrin CoQ10 complex in liquid and dry form.  The greatest accumulation of CoQ10 in cells occurred with #8 Hydro-Q-Sorb (CoQ10 gamma cyclodextrin complex) with 739% uptake, closely followed by #7 Liquid-Q (VitaSperse CoQ10) with 693% uptake.      

    

References 

  1Murphy SL, Kochanek KD, Xu JQ, Arias E. Mortality in the United States, 2014. NCHS data brief, no 229. Hyattsville, MD: National Center for Health Statistics. 2015.  

2Mozaffarian D, Benjamin EJ, Go AS, et al. Heart Disease and Stroke Statistics-2016 Update: A Report From the American Heart Association. Circulation. 2016;133:e38-e360.  

3Arenas-Jal M, et al.  Coenzyme Q10 supplementation:  Efficacy, safety, and formulation challenges.  Comp Rev Food Sci Food Saf 2020 (19): 574-594.   

4Hernándex-Camacho JD, et al.  Coenzyme Q10 supplementation in aging and disease. Frontiers in Physiology 2018 (9):44.  

5Qu H, et al.  The effect of statin treatment on circulating coenzyme Q10 concentrations: an updated meta-analysis of randomized controlled trials. Eur J Med Res 2018(23): 57.   

6 Mazidi M, et al.  Effects of coenzyme Q10 supplementation on plasma C-reactive protein concentrations: A systematic review and meta-analysis of randomized controlled trials. Pharmacological Research 2017, http://dx.doi.org/10.1016/j.phrs.2017.08.011   

7 Tabrizi R, et al.  The effects of coenzyme Q10 supplementation on blood pressures among patients with metabolic diseases: A systematic review and meta-analysis of randomized controlled trials. High Blood Press Cardiovasc Prev (2018):14-50.   

8 Gao L, et al.  Effects of coenzyme Q10 on vascular endothelial function in humans: A meta-analysis of randomized controlled trials. Atherosclerosis (2012):311-316.   

9 Bhagavan, et al.  Assessment of coenzyme Q10 absorption using an in vitro digestion-Caco-2 cell model. International Journal of Pharmaceutics (2007):112-117.